Recovery of Lupus Erythematosus

Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage mediated by tissue binding auto antibodies and immune complexes. SLE diagnosis is based on certain clinical symptoms and auto antibodies.

Diagnostic criteria for SLE:

1. Malar rash

2. Discoid rash

3. Photosensitivity

4. Oral ulcers

5. Arthritis

6. Serositis

7. Renal disorder

8. Neurologic disorder

9. Hematologic disorder

10. Immunologic disorder

11. Antinuclear antibodies

If any four or more combinations of these 11 criteria have been well established at any time during the course of disease in a patient, it is probable that the patient has SLE.

At onset, SLE may involve one or more organ systems and additional manifestations may occur later as time passes. Most patients experience exacerbations interspersed with periods of relative quiescence. True permanent remissions (with no symptoms and no therapy) are rare. Systemic symptoms especially fatigue and musculoskeletal pains are usually present. A severe systemic disease which requires Glucocorticoid treatment can be accompanied by fever, fatigue, weight loss, anemia and other manifestations which target limbs.

Musculoskeletal manifestations: Most patients with SLE have intermittent polyarthritis (from low intensity to disabling) which is characterized by swelling of the soft tissues and sensitivity to touch in the joint areas (in most cases in PIP&MCP joints of the hand, wrist and knee). Cutaneous manifestations: Lupus dermatitis can be divided in to Discoid Lupus Erythematosus (DLE), systemic rash, Subacute Cutaneous Lupus Erythematosus (SCLE) or others.

Renal manifestations: Nephritis is usuallythe most severe manifestation of SLE; particularly as nephritis and infection are the foremost causes of death in the first decade of the disease. In most patients with SLE nephritis is asymptomatic; therefore urine analysis must be performed on any patient with suspected SLE. Nervous system manifestations: SLE has many manifestations in the Central (CNS) and peripheral nervous systems. Vascular obstructions: Prevalence of transient ischemic attacks, brain infarction and myocardial infarction increases.

Pulmonary manifestations: The most common pulmonary manifestation is SLE Pleuritis with or without pleural effusion. Pericarditis is the most prevalent Cardiac manifestation. This disorder usually responds to anti-inflammatory treatments and occasionally leads to tamponade. Hematologic manifestations: The most common Hematologic manifestation is SLE anemia, generally normochrome normocyte which is an indication of a chronic disease. Gastrointestinal manifestations: Nausea (sometimes with vomiting) and diarrhea can be manifestations of an SLE attack. Ocular manifestations: Sicca Syndrome and non-specific Conjunctivitis are common in SLE and occasionally threaten vision.

Treatment of Systemic Lupus Erythematosus

There is no cure for SLE and complete remissions are rare. Therefore physician should plan to control acute, severe flares and to develop maintenance strategies in which symptoms are suppressed to an acceptable level and damage to organs is prevented. Usually patients will be affected by some adverse drug side effects.

The fundamental treatment for each organ or life-threatening inflammatory manifestation in SLE, is systemic Glucocorticoids, Methylprednisolone Sodium succinate IV (intra venous) and daily prednisone or its equivalent.

Along with Glucocorticoids, Cytotoxic/ immunosuppressive drugs are recommended for treatment of severe SLE. Approximately all controlled prospective studies on SLE which include Cytotoxic drugs, have been performed on patients with Lupus nephritis; always accompanied with Glucocorticoids.

Early treatment with a combination of Glucocorticoid and Cyclophosphamide slows down progression toward ESRD and enhances the patient’s survival. As treatment with Glucocorticoid plus Cyclophosphamide has many undesirable effects and frequently patients don’t desire this, some research has been undertaken for other possible treatments which have less toxic effects.

Case presentation

The patient is a 39 year old married woman who lives in Tehran and is a known case of LE Lupus Erythematosus since 1369 Persian calendar (1990). The illness started with joint aches in fingers and progressive weakness.

The joint aches spread in to the shoulders and gradually to the whole body along with extensive swelling; to the point where she could not move. Upon referral to different physicians, unfortunately, Rheumatoid arthritis was diagnosed and she was treated as an outpatient for months. Only when kidney and skin problems (as cutaneous macular lesions) appeared, was she seen by an expert urologist, diagnosed as a lupus case and finally hospitalized, where she underwent treatment in 1379 (2000). (Appendix 1) The patient had been treated with Cyclophosphamide plus corticosteroid and because of acute nephritis and severe renal insufficiency underwent dialysis in early 1370 (1991). (She underwent 7 rounds of dialysis and 2 to 3 rounds of plasma phoresis in 6 months and each month received treatment pulses of Cyclophosphamide plus corticosteroid).

Then the kidneys almost resumed and there was no need for further dialysis. Up to 1381 (2002), she had flare ups of acute signs approximately three times a year, in which the same treatment was repeated. Nevertheless she was hospitalized along with severe fever and chills in the Urology Research Centre of Shariati hospital in Mehr 1381(September 2002). (Appendix 2)

Work up with FUO diagnosis was performed and she underwent broad spectrum antibiotics for 3 weeks and due to the continuation of fever she remained hospitalized. CBC results showed anemia, microcytosis and Target cell tear drop, and Hb didn’t rise above 8.8 during the whole period of illness (Appendix 2). In sonography kidneys, liver and spleen appeared normal, only several cystic areas in the uterus and cystic ovaries were observed and through gynecological consultation vaginal cyst aspiration or laparoscopy was recommended.

With an increased dose of Prednisolone to 60 mg/d plus Cyclophosphamide, she left the hospital however; flare ups of acute signs still continued until Azar 1386 (November 2007) until she was introduced to Faradarmani courses. According to the patient’s own words, upon the first course of Faradarmani, the clinical symptoms disappeared in such a way that at the end of the first course of Faradarmani; arthlargia, weakness, proteinuria and anemia completely disappeared (Appendix 3).

During the past two years, not only has the patient not had the flare ups of the illness, but she also feels better and better day by day and the follow up test results in 1387(2008) were totally normal including BUN, Cr,C3, C4 and Hb (Appendix 4 & 5). Also in recent studies in 1388 (2009), the above results continue to remain normal (appendix 6, 7, 8) and for the first time her Hb was above 12. According to the patient’s own words, the world has changed for her during the past two years of her life; less pain and illness and more love.

Discussion

As we mentioned at the beginning of this article, lupus, especially along with renal disorder and involvement of the main organs, not only has the possibility to relapse, but it also has no cure. Therefore physicians should plan to control acute, severe flares and to develop maintenance strategies in which symptoms are suppressed to an acceptable level and damage to organs is prevented. Usually patients will be affected by some adverse drug side effects. Along with Glucocorticoids, Cytotoxic drugs are recommended for treatment of severe SLE, and because of many undesirable side effects several researches for other possible treatments are going on. The above patient, without the interference of any drugs and with the use of Faradarmani treatment, all clinical symptoms have disappeared and numerous problems have been solved.

Conclusion

In the view that Faradarmani establishes a consciousness bond between the “whole” consciousness and the “parts”; this bond can play an important role in repair, correction and elimination of the defective cellular consciousness.

In the above patient it is observed that this type of treatment is able to solve the patient’s problems without any adverse effect, furthermore, in a very short time. The follow up test results all confirm that it is possible to consider Faradarmani as an effective solution in treating a wide range of illnesses, moreover without relapse of the illness.

 Patient’s Consent

The patient has given full consent to publish this report.

 Patient’s view

She is not only satisfied with the treatment results, but is also introducing Faradarmani to other patients so that this Divine Merci passes on to others as well.

 Documentation and evidence

The original report of all test results is available at the journal’s office.

 Faratherapists

Members of Faradarmani Medical Research Group

 Resources

1. Mohamad Ali Taheri, Human From Another Outlook, Bijan publication 1388 (2009).

2. Rheumatologic Diseases and Immune System, Harrison 2008, Tehran Arjomand Publication 1387 (2008).

Appendix

 

Appendix 1

Appendix 2

Appendix 3

Appendix 4

Appendix 5

Appendix 6

Appendix 7

Appendix 8

Patient’s own testimony

In the Name of God

I am a 39 year old woman, born in 1349 (1970). The name of my illness is Lupus (it means wolf in Latin) and started from year 1368 (1989) as a result of stress for university entrance exam.

At that time I was a jealous, vain, irritable, sensitive and arrogant girl who ignorantly was making her own life miserable. These, also, were the inward causes of my illness relapse. At the beginning I didn’t know why my shoulders were so sore and my joints were swollen. Gradually all my body became stiff and painful, pain was so intense that I could not even move my fingers. Several doctors all made the wrong diagnoses for almost a year. They did several other diagnoses except for Lupus and naturally prescribed wrong medications which made my situation even worse and caused my kidneys to stop working. Finally, an expert physician who was kind and caring immediately diagnosed my illness and then monthly chemotherapy (Cortontherapy and cyclophosphamide pulses) started up to 9 months. This continued for every 2, then 3, 4, 6 months and then stopped. My kidneys resumed working after 7 times dialysis and 2 to 3 times plasma phoresis, which itself was a miracle. However I still had proteinuria and was under the care of my professional caring doctor.

Gradually I felt better, went to university, got married and became a teacher. However periods of relapse and relief continued at least once a year till year 1381(2002) in which the disease attacked intensely. Fever up to 40 degree and the after chills didn’t leave me with any energy. Powerful antibiotics were injected in the hospital and after one hell of a month, my illness was under control again. However this time, because of my illness, my husband left me; although he was aware of everything when he married me.

Surprisingly; I felt blessed after my divorce seeing that my poetic talent which had become dormant in childhood, once again blossomed and I was able to express my feelings through poems.

At that time I didn’t know what God’s promise was, but the poems were pouring from deep in my heart. Tears were flowing from my eyes and I was feeling that all my being is yearning for something, but I could not find it. I read a lot of books and was looking for my missing piece in spiritual books; from Eastern to Western. I tried physical exercise, yoga, diets and several other treatments which I found all very useful, however, I still could not find what I was looking for ; until Azar 1386 (Nov. 2007); when I was introduced to Erfan Halgheh (Faradarmani) courses of Master Taheri and I felt I finally found my missing piece. At that time, I was depressed and lost spiritually, also my cortontherapy was again increased. I immediately enrolled to the course and I finished the first Level with a lot of enthusiasm. In that short period of time my medical test results became normal and I felt strong and uplifted, but still I was looking for something beyond physical wellness. The second Level was my first step toward Kamal (Kamal literally means completeness and here refers to the human spiritual growth) and Erfan (pursuit of achieving conscious awareness of the ultimate reality). At the moment I am continuing the courses and I feel more energetic, healthier and better day by day in all aspects of my life. My old attitude has changed; love, kindness and smile have replaced it. My perception and understanding of humans, nature, universe and God has fundamentally changed and I feel I can distinguish the way from by-way. I am aware now that «dis-ease» is the pressure of the negative thoughts and deeds and I understood that the way to freedom is to step into Kamal pathway and to achieve good thoughts, good words, and good deeds. It’s the way to help people, it’s the way to be in peace with nature. I feel I have become a channel in which love and yearning to help others are flowing through and me has been transformed to us.